VPB 321: Animal Biotechnology (2+1)

SYNTHESIS AND BIOLOGICAL FUNCTIONS OF APPs

• The synthesis of APPs is thought to be stimulated by monokines such as IL-1, IL-6 and tumor necrosis factor (TNF).
• Although the response pattern of individual APPs to various stressors or disease may differ, changes in their plasma concentrations are generally regarded as being sensitive, although non-specific, indicators of inflammation.
• The biological functions of APPs are also highly variable with some functioning as proteinase inhibitors, enzymes, transport proteins, coagulation proteins, and modulators of the immune response.
• However, all APPs appear to play a role in the restoration of homeostasis after injury, tissue necrosis, or infection.