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Germ Theory of Disease
1. The organism is regularly found in the lesion of the disease.
2. It can be isolated in pure culture. 3. Inoculation of this culture produces a similar disease in experiments on animals. These criteria have proceeded invaluable in identifying pathogens, but they cannot be met: some organism such as viruses cannot grow on artificial media and some are pathogenic only for man. Golden era of microbiology was established between 1860 and 1910 because of development of powerful methodology. Moreover, various members of the German school isolated (in addition to the tubercle bacillus), the cholera vibrio, Typhoid Bacillus, Diphtheria, Bacillus, Pneumococcus, Staphylococcus, Streptococcus, Meningococcus, Gonococcus and Tetanus bacillus.
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Last modified: Friday, 9 December 2011, 8:12 AM