VPT 321: Veterinary Neuropharmacology (2+1)

Selective Muscarinic Receptor Antagonisis

SELECTIVE MUSCARINIC RECEPTOR ANTAGONISTS

 Selective M₁ Muscarinic Receptor Antagonists

• Pirenzepine
  • Inhibit gastric acid secretions at doses that do not produce other effects. It has minimal CNS effects as it cannot pass the BBB.
• Telenzepine
  • Analogue of pirenzepine and it is more potent than pirenzepine. Used in the treatment of peptic ulcer.

 Selective M₂- Muscarinic Receptor Antagonists

• Tripitamine
  • Has potential for clinical use as drug for blocking cholinergic bradycardia

Selective M₃- Muscarinic Receptor Antagonists

• Darifenacin
  • Useful in smooth muscle activity or epithelial secretions.