Opioid interactions

OPIOID INTERACTIONS

CNS depressants with OPIOID often potentiate  an additive depression

  • OPIOID and phenothiazines 
    • produces an additive CNS depression as well as enhancement of the actions of OPIOID (respiratory depression)
    • Produce a greater incidence of orthostatic hypotension
  • OPIOID and tricyclics antidepressants -Produce increased hypotension
  • Meperidine and MOA inhibitors - results in severe and immediate reactions that include excitation, rigidity, hypertension, and severe respiratory depression
  • OPIOID and barbiturates - increased clearance of opioids
  • OPIOID and amphetamine - enhanced analgesic effect
Last modified: Wednesday, 16 May 2012, 5:08 AM