Patulin is a mycotoxin produced by Penicillum expansum. The mold and mycotoxin are produced when the fruit deteriorates. Patulin is toxic to Gram-positive and Gram-negative bacteria and was once considered for use as an antibiotic. However, patulin was too toxic (LD 50 of 15 to 35 mg/kg) and was shown to induce tumors. The mycotoxin is unstable in alkaline conditions but stable under acidic conditions, and adding ascorbic acid inactivates the mycotoxin.
Last modified: Thursday, 23 February 2012, 9:51 AM