Cornybacterial infections
CORYNEBACTERIM INFECTION (ACTINOMYCES PYOGENES)
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Definiton
Cornybacterium
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Disease
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C. diphtheriae
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Humans
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C. renale
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Pyelonephritis, ureterits, cystitis in cows; haemarrhagic cystitis and pyelonephritis in cows
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C. pilosum
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Cystitis and pyelonephritis in cows
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C. pseudo tuberculosis C. ovis
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Caseous lymphadenitis in sheep and goats ulcerative lymphangitis and pectoral abscesses in horses
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C. bovis
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Pyelonephritis and cystitis in pigs
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C. suis
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C. pyogenes (Actinomyces pyogenes)
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Suppurative infection in cattle, sheep, ,goats and pigs;summer mastitis in cattle
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C. ulcerans
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Wound infections and abscess
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C. equi (Rhodoccous equi)
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Pneumonia in horses
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OVINE CASEOUS LYMPHADENITIS (Pseudotuberculosis of sheep & Goats)
Definition
Transmission
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Way of abrasion
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Inhalation
Pathogenesis
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Infection through skin
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Development of abscess in lymph nodes
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Organisms is intracellular
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Resistant to destruction
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Produces exotoxin and high lipid content of bacterial cell wall which helps in survival
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Haematogenous spread of organism
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Abscess in many organs like lung, liver, kidney , brain , spinal cord
Clinical signs
Gross lesions
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Abscesses of lymph nodes
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Enlargement of lymph nodes
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A single spherical lesion
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Upon cross section concentrically laminated
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Layers of fibrous capsule alternate with caseous friable material which is greenish and gritty
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In lungs, greenish to yellow pus
Microscopic lesions
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Small focus of epithelioid cells ; Central caseous necrosis; surrounded by thin layer of fibrous connective tissue, epithelioid cells and lymphocytes
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As lesion grow, the epithelioid and fibrous reactive layers undergo necrosis
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New reactive layers form outside as necrosis occurs
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A spherical, onion like concentric laminated mass is seen
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Calcification without giant cells, seen
Diagnosis
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Examination of pus taken for needle biopsy
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Isolation of causative organism with diphtheroid morphology and cultural characteristics
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Serological tests – indirect haemagglutination, hemolysis inhibition immuno diffusion, ELISA
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Last modified: Wednesday, 21 March 2012, 10:47 AM