Systematic Veterinary Virology

PRE EXPOSURE PROPHYLAXIS

• Persons who are regularly at high risk of exposure, such as vets, laboratory workers, animal handlers and wildlife officers should be considered for preexposure prophylaxis by active immunization with the cell culture vaccine.
• Immunization normally consists of 3 doses of vaccine. Antibody can be demonstrated in the sera of virtually 100% of those vaccinated if the diploid cell culture vaccine is used.
• Booster doses should be offered to persons at continuing risk every one to three years. Local treatment of wounds should always be carried out in exposed persons who have been vaccinated previously.