Veterinary Physiology-III

SOMATOSTATIN (SOMATOTROPION RELEASE-INHIBITING HORMONE - SRIF)

• It is a hypothalamic peptide present in two forms - 14 and 24‑28 amino acids, also present in pancreas
• Potent inhibitor of GH, also inhibits TSH, PRL and ACTH, insulin and glucagon.
• Its production is stimulated by GH release from the pituitary, ingestion of carbohydrate, fat, protein, and high level of glucose, amino acids, increased output of glucagon, gastrin, VIP, secretin, CCK, acetylcholine and b adrenergics.
• Somatomedin C (from the liver), dopamine, insulin, estrodiol and a -adrenergics inhibit the release of somatostatin.
• Somatostatin has been isolated from brain, pancreas and intestine.