Veterinary Immunology and Serology

FUNCTION OF NEUTROPHILS

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Function

• They move to the site of infection (during inflammation).
• Phagocytosis.
• The contents of primary granules perform many functions like,
  • defensins kill gram-positive bacteria;
  • myeloperoxidase cause respiratory burst;
  • neutral and acid hydrolyses degrade bacterial products;
  • lysozyme destroy bacterial cell wall.
• The contents of secondary granules lysozyme (both from primary and secondary granules) destroy bacterial cell walls, lactoferrin binds iron and collagenase degrades connective tissue.
• Neutrophil destroy all ingested foreign materials and they cannot process antigen for presentation to antigen sensitive cells.