Veterinary Immunology and Serology

BASOPHILS AND MAST CELLS

Basophils

• Derived from bone marrow and have many of the same properties as tissue mast cells. It is the smallest of the granulocytes.
• Like mast cells, they bear Fc receptors for IgE and contain histamine rich cytoplasmic granules.
• They are not normally seen in the extra vascular tissues, but may infiltrate tissues under the influence of lymphocytes.

Mast cells 

• Bone marrow derived, resident cells essential for IgE mediated inflammatory reactions. Cytoplasm is densely packed with granules.
• Granules have large amounts of histamine, heparin, TNF-α and other inflammatory mediators.
• Also contain enzymes like super oxide dismutase, peroxidase and acid hydrolases.
• Mast cells are scattered in connective tissues in large numbers beneath skin, lung alveoli, gastro intestinal mucosa and nasal mucous membranes.