Pathogenesis

PATHOGENESIS
  • Initiated by ischemia, nephrotoxins, or intrinsic renal disease; renal excretory failure is perpetuated by multiple factors including
    • reduced glomerular surface area and permeability
    • low renal blood flow
    • intratubular obstruction by tubular debris
    • cellular and interstitial edema
    • “backleak” of filtrate across damaged tubular epithelia;
    • resolution occurs by renal regeneration and repair
Last modified: Wednesday, 9 March 2011, 2:55 AM