Causes

Clinical Nutrition
Lesson 18: Cirrhosis and Portal hypertension

Causes

Excessive alcohol consumption

  • Deficiency of proteins, carbohydrates and vitamins
  • Affects lipid metabolism by
  • Fatty acid synthesis
  • Fatty acid oxidation
  • Stimulation to produce triglycerides
  • Release of lipoproteins
  • Uptake of circulatory lipids
  • Risk of hepatitis B and C
  • Malnutrition: Deficiency of Vitamin A, β-carotene, Vitamin E and C
  • Iron overload (Heamochromatosis), Wilson's disease (disturbance in Cu metabolism)
  • Chronic viral hepatitis B,C,D and G
  • Chronic bile duct obstruction
  • Aflatoxins

Presence of drugs and toxins like aflatoxin.

  • Malnutrition
  • Intestinal by pass
  • Vascular disorders
  • Metabolic disorders

Hemo chromatosis – where in excess of iron is deposited.

Wilsons disease – where in copper is present in free form due to the deficiency of ceruloplasmin.

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Last modified: Saturday, 5 November 2011, 5:51 AM