Fish Immunology (1+1)

Unit 5- Specific defence mechanism in Fish

5.1.3. Helper T cells
These T cells are activated when macrophages-bound antigen linked to class II Major Histocompatibility Complex (MHC) in the presence of interleukin-l and they secrete two factors like B cell growth factor (IL-4) and B cell differentiating factor (IL-5). The IL- l, IL-4 and IL-5 act together to provoke B cell to respond quickly.