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7.5.1.Translation
The initiation of protein synthesis in human cells begins when mRNA attaches itself to the surface of a small ribosomal subunit such that its first codon, which is always the initiating codon AUG, occupies a site called the P site(peptidyl site). An activated tRNA molecule with anticodon complementary to the codon AUG attaches itself, through complementary base pairing the AUG codon. The resulting complex then interacts with a large ribosomal subunit to complete the formation of an initiation complex. Since the initiating codon AUG codes for the amino acid methionine, the first amino acid in a developing protein chain will be N-formyl methionine. |
Last modified: Wednesday, 22 February 2012, 9:31 AM