Penetration enhancers

PENETRATION ENHANCERS
  • Chemical penetration enhancers act by improving penetration by reversibly damaging stratum corneum or by altering the stratum corneum to reduce the resistance to diffusion.
    • Azone& derivates
    • Urea and derivatives-1- dodecyl urea, 1,3 decyl urea ,propylene glycol
    • Terpene - carrone, pulegone, menthone
    • Aprotic solvents- DMSO, 2-pyrrolidone
    • Surfactants such as polyethylene glycol
  • Suitable use of penetration enhancers would help increase the bioavailability of agents given intradermally.
Last modified: Thursday, 26 April 2012, 5:44 AM