H2 receptor antagonist

H2 RECEPTOR ANTAGONIST

  • H2 receptor antihistamines are: Cimetidine, Ranitidine, famotidine, Roxatidine, Nizatidine, Loxatidine
  • These are the most popular drugs for peptic ulcer.
  • Cimetidine(prototype example), ranitidine,nizatidine and roxatidine are competitive in action
  • Famotidine competitive and non competitive in action
  • Loxatidine is non competitive in action
  • H2 antagonists block histamine gastric secretion, cardiac stimulation (in guinea pigs), uterine relaxation (in rat), and bronchial relaxation
Last modified: Tuesday, 15 May 2012, 8:03 AM