VPT 321: Veterinary Neuropharmacology (2+1)

RIGHTING REFLEX 

• Groups of 10 female mice are injected (View video) subcutaneously with a test substance. 
  • After 15,30,60,120,180,240 and 300 minutes each animal is placed gently on its back and an undulated surface and kept up to 30 seconds.
  •  If the animal remains on the back for 30 seconds, loss of righting reflex is said to occur.