VPT 321: Veterinary Neuropharmacology (2+1) copy 1

ADRENERGIC RECEPTOR ANTAGONISTS

• These drugs interact with adrenergic receptors (α and / or β) on effector cells (post junctional) or on adrenergic neurons ( pre junctional) and prevent their access to either endogenous catecholamines or exogenous adrenergic drugs, except phenoxybenzamine, almost all these drugs act as competitive antagonists.
• These are further divided into three groups, based on the type of receptors they antagonize:
  • α receptor antagonists (selective and non selective)
  • β receptor antagonists (selective and non selective)
  • α and β receptor antagonists