VPT 321: Veterinary Neuropharmacology (2+1) copy 1

DRUGS THAT INHIBIT NORADRENALINE REUPTAKE

• Neuronal reuptake of released noradrenaline (uptake1) is the most important mechanism by which sympathetic neurotransmission is terminated.
• Thus drugs that inhibit this uptake1 process cause accumulation of noradrenaline in synaptic cleft, which results in enhancement of sympathetic activity.

Tricyclic antidepressants

• Drugs like imipramine and desimipramine block noradrenaline and 5HT uptake by nerurons. Major effects are seen in the central nervous system with this group of drugs.

Cocaine

• It is an alkaloid obtained from Erythroxylum coca with  local anaesthetic alkaloid. Besides the local anesthetic action, cocaine also blocks Na⁺-K⁺-activated ATPase required for transport of noradrenaline into neurons across the cell membrane (uptake1)