Classification and pharmacokinetics of NSAIDs

CLASSIFICATION AND PHARMACOKINETICS OF NSAISs

Classification

NSAIDS

Poorly anti-inflammatory

  • Para-aminophenols - Paracetamol
  • Pyrazolones - Dipyrone, Propiphenazone

Pharmacokinetics

  • NSAIDs are weak acids
  • Well absorbed after oral administration
  • Highly protein bound and have poor Volume of distribution
  • Displacement from albumin binding by other substrates is possible
  • Metabolized in liver.
  • Conjugates excreted in urine
  • Age and species variation plays an important role in pharmacokinetics
Last modified: Saturday, 15 October 2011, 5:28 AM