Kinetics of opioids

PHARMACOKINETICS OF OPIOID

  • Readily absorbed from GI tract, nasal mucosa, lung, subcutaneous, intramuscular and intravenous route
  • Wide distribution
  • Has wide volume of distribution
  • Free morphine accumulates in kidney, lung, liver, and spleen
  • CNS is primary site of action (analgesia/sedation) - Biotransformation in liver - Conjugates with glucuronic acid
  • Excreted by kidney
  • Half life is 2.5 to 3 hours (does not persist in body tissue)  
Last modified: Wednesday, 16 May 2012, 4:52 AM