Procedure for convulsions induced by electroshock

INFERENCE

Convulsion induced by electroshock

  • The animals of choice for this experiment are adult male rats or mice. At some interval before electroshock a test substance (anticonvulsant) dissolved in a suitable vehicle is given by the subcutaneous or the oral route or intraperitoneal route.
  • The maximal electroshock test is a measure of the ability of an anticonvulsant drug to abolish the tonic, extensor component of the hind limb in the maximal seizure pattern induced by 50 mA of current (mice) or by 150 mA (rats) delivered for 0.2 second.
  • Substances are compared in groups of 5 to 6 animals. Phenobarbital (10 to 30 mg/kg) may be employed to demonstrate anticonvulsant activity.

Results:  Date:   Route:   Inference:

S.No

Sex of the animal

Weight of the animal

Dose of the test substance

Time of administration of test substance

Maximal electroshock administered in mA

Status of animal survival / death

% of protection

1

2

3

4

5

6

Last modified: Monday, 18 June 2012, 7:08 AM