VLD 411: Veterinary Clinical Biochemistry and Laboratory Diagnosis - I (0+1)

CLINICAL SIGNIFICANCE

Estimatin of urea and BUN

Normal Value

• Dog : 12-25 mg/dl
• Bovine : 20-30 mg/dl

Clinical Significance

• Decreased level of BUN in
  • Protein malnutrition
  • Hepatic insufficiency
• Increased level of BUN noticed in
  • Physiological factors (Pre Renal )
    • High protein diet, dry food and canned food.
    • Catabolic break down of tissue as consequence of fever ,trauma, infection and toxemia.
    • Haemorrhage into gastrointestinal tract
    • Iatrogenically by administration of certain drugs
    • Anything that reduce renal blood flow
      • Cardiovascular disease
      • Shock (septic or traumatic)
    • Factors that reduce net Glomerular filteration pressure
      • Hypotension
      • Shock
      • Adrenocortical insufficiency
      • Dehydration
      • Increased protein osmotic pressure
  • Renal 
    • Elevation of BUN occur when approximately 70% of nephron are non functional
  • Post Renal Uremia
    • It occurs with obstruction or rupture of excretory pathway of urine ( ureters, bladder and urethra)  and enlargement of prostate gland