VPT 421: Veterinary Toxicology (2+0)

FACTORS AFFECTING TOXICITY

• Nitrates from plants are converted into nitrites in the rumen. These excessive nitrites are absorbed into circulation.
• Pigs are more susceptible than cattle and sheep.
• Fasting increases toxicity.
• Rate of intake , variations in gastrointestinal nitrate reduction, diet, metabolic state of the animal, pregnancy are some factors affecting toxicity.
• The amount of preformed nitrite influences toxicity in monogastric animals.
• Foetuses and neonates are more susceptible.