VPT 421: Veterinary Toxicology (2+0)

ABSORPTION AND FATE

• Organochlorines are readily absorbed from skin and mucous membrane as they are highly lipid soluble.
• Organochlorines are not highly volatile and hence inhalation is not a major problem. But aerosols can be absorbed.
• Organochlorines are distributed to vital organs namely liver, kidney and brain. But they do not get accumulated in the vital organs.
• They readily accumulate in the lipid depots.
• Metabolism is mainly by mixed function oxidases and the metabolite may be non toxic than the parent compound.
• Dieldrin and heptachlor epoxide are persistent in the body and the environment.
• Excretion is mainly in the faeces and in lactating animals, it is excreted in milk.