VPT 421: Veterinary Toxicology (2+0)

CLINICAL SYMPTOMS AND PM LESIONS

• Clinical symptoms
  • Initial stimulation of CNS followed by depression and death due to respiratory failure.
  • Behavioural changes like anxiety, aggressiveness, abnormal posturing, jumping over unseen objects, wall climbing and madness syndrome, neurological symptoms like hypersensitivity to external stimuli, fasciculation and twitching of facial and eyelid muscles, spasm and twitching of the fore and hind quarter muscles, champing of the jaws, seizures, pivoting on one foot, fall over backwards and hyperthermia and chloinergic symptoms like vomiting, marked salivation, mydriasis, diarrhoea and micturition are noticed.
  • In birds there will be sudden death after depression, disorientation, abnormal posture and apparent blindness.
• Lesions
  • Large doses may sometimes cause centrolobular necrosis of liver and smaller doses cause liver enlargement