VPT 421: Veterinary Toxicology (2+0)

CONSUMER SAFETY

• The criteria for ultimate consumer safety include NOEL, ADI and safety factor.
• NOEL is the highest dosage level leading to no observable morphologic or functional changes in the test animal.
• Safety factor reflects the quality of the toxicologic investigations and the degree of certainty with which results can be extrapolated to humans.
• ADI is the amount of residues that can be ingested for a lifetime without fear of deleterious health effects.
• Any tolerance level for residues in food is obviously a function of the amount of food item ingested by the consumer and this is known as the food factor.
• Human exposure is based on the residue in target tissues.