Veterinary Taxicology

CELLULAR DYSFUNCTION AND INJURY

Cellular dysfunction and injury - The toxicant after interaction with the target molecule causes cellular dysfunction and injury, and no repair mechanism can prevent this stage. For example, after ingestion, tetradotoxins reach the sodium channels and block these channels and cause excess muscle paralysis. The dysfunction may be either at the cell signalling stage or at the cell regulation stage.

Development of toxicity by alteration in the regulatory functions or maintenance functions of the cell