Veterinary Preventive Medicine-II

PREVENTION AND CONTROL

Vaccination

• Laprinised vaccine : Immunity last for 1-7 years
• Goat tissue vaccine : Immunity last for 13 years or life long

• In countries where Rinderpest is exotic, confirmed outbreaks are controlled by the slaughter and disposal of all affected and in contact animals, as well as by appropriate quarantine and animal movement controls
• All outbreaks of rinderpest in virgin areas have been due to the importation of live infected animals.
• Prevention in such areas is therefore largely dependent upon vigilant control of the introduction of live animals from potentially infected areas
• Contaminated areas should be physically cleaned of all animal waste and soiled bedding and treated with disinfection solutions of high (>10) or low (<3) pH containing solvents to destroy the virus envelope. Solutions of caustic soda and Lysol have the highest virucidal activity against virus contaminated with organic matter
• Attenuated tissue culture (bovine kidney cells, vero cells) Kabete “O” strain of RPV produced a totally safe and effective attenuated virus which has been the principal vaccine used to combat rinderpest through out the world during the past 40 years. It induces a life long immunity, inexpensive and simple to produce and stable in freeze dried form.
• The only drawback of the vaccine is that after reconstitution in normal saline it has a working life of only a few hours in the hot climates
• Recombinant vaccines in which genes expressing RPV immunizing antigen are incorporated into more thermostable pox viruses have been developed and used for differentiating vaccinated animals with the infected animals and thus helps in eradication of disease
• In endemic areas calves at the age of 6-12 months vaccinated for RP. Annual vaccination of all cattle will produces highest levels of herd immunity.