Veterinary Immunology and Serology

DIFFERENCE BETWEEN B AND T CELLS

	Features	B cells	T cells
1.	Origin	Bone marrow	Bone marrow
2.	Mature with	Bursa , Bone marrow, Payer’s patches	Thymus
3.	Distribution	Lymph node cortex, Splenic follicles	Lymph node -paracortex, Spleen -periarteriolar sheath
4.	Circulate	No	Yes
5.	Life span	Short (few days to few weeks)	Long (more than 1 year usually 6 months to 10 years)
6.	Surface immunoglobulin	Present (IgM, IgD, IgG)	Absent
7.	Immunity type	Humoral	Cell mediated
8.	Secreted products	Immunoglobulins	Cytokines
9.	Response to mitogens	Pokeweed, Lipopolysaccharides	Phytohaemagglutinin (PHA), Cconcavalin-A, BCG Vaccine, Pokeweed
10.	EAC Rosette formation	Yes [ B cell bind to sheep RBC coated with antibody and complement due to (C3 receptor or CR2 on B cell surface)].	No
11.	E or SRBC rosette formation	No	Yes (T cell bind to sheep RBC due to CD2 antigen on T cell surface]
12.	Production pathway	Short	Long
13.	Antigen uptake	Can take up unprocessed antigen	Only processed antigen
14.	Diversity	No diversity in function	Diverse in function
15.	No. of subsets	No subset or very few	Subsets present