Veterinary Immunology and Serology

BLOOD GROUP ANTIGEN

• The antigens found on the surface of red blood cells are called blood group antigens or erythrocytes antigens.
• Earlier attempt of blood transfusion often resulted in disastrous consequences.
• Blood transfusion became scientifically feasible after the discovery of blood groups by Landsteiner (1900).
• Most of the blood group antigens are either glycoprotein or glycolipids and they are the integral components of cell membrane.
• They are not involved in antigen processing but they influence graft rejection.
• There are several human blood group system e.g., ABO, MN, Rh, Lewis, Kell, Duffy, Kidd, Colton etc.,
• Function:
• The ABO antigens in human are anion and glucose transporter proteins.
• The M and C antigen of sheep RBC are associated with membrane potassium pump and amino acid transport.