Diagnostic Laboratory Section

SIGNIFICANCE AND INTERPRETATION

Significance

Neutrophilia

• Acute infections, especially in pneumonia, metritis, pyometra, meningitis, rheumatoid arthritis etc
• Localised pyaemic infections like abscesses, furancle, otitis etc
• Intoxication like uraemia, gout, diabetic acidosis and drug poisoning like lead, mercury and insect venom
• Tissue necrosis, acute haemorrhage or sudden haemolysis
• Post operative phase and trauma
• Tumours, coronary thrombosis, granulocytic leukaemia and myeloid leukaemia
• Physiologically it may be seen during late pregnancy, exercise and epinephrine response. 

Neutropaenia

• Overwhelming bacterial infections, viral infections, Toxic conditions and  etc. 

Lymphocytosis

• Infectious hepatitis, bacillary infections, convalescence from acute or chronic   infections like TB
• Chronic suppurative inflammation
• Goitre, lymphoma, lymphocytic leukaemia
• It is normal in young animals.  Relative increase is seen in  neutropaenia and hyperthyroidism.

Lymphopaenia

• Immunosuppressive drugs (corticosteroid treatment)
• Viral infection
• Radiation

Monocytosis

• Chronic infection or inflammation.
• TB, subacute bacterial endocarditis, brucellosis, swine erysipelas and listeriosis 
• Monocytic and myelomonocytic leukemia
• Granulomatous diseases
• Relative increase in neutropaenia
• E. canis

Monocytopaenia

• Acute infection or inflammation
• Corticosteroids in some species

Eosinophilia

• Allergic conditions 
• Skin diseases
• Parasitic diseases
• Tropical eosinophilia and eosinophilic myositis
• Following radiation therapy
• Tumours of ovary, serous surfaces and bones 
• Eosinophilic leukaemia
• Poisons like copper sulphate, phosphorous, camphor etc.

Eosinopaenia 

• Epinephrine
• Corticosteroids
• Acute infection

Basophilia

• Chronic sinus inflammation
• Chronic haemolytic anaemia
• Foreign protein infection and Hodgkin’s disease
• Basophilic leukaemia and granulocytic leukaemia