General Parasitology and Helminthology: Pathogenesis

Pathogenesis

PATHOGENESIS

In the intestine they produce a condition known as pimply gut or knotty gut.
Lambs and older sheep that are exposed for very first time to this parasite will not have any resistant to this parasite, hence the larvae incite practically no reaction during migration into intestinal mucosa.
Eventually large number of adult worms emerge occur but nodule formation will not take place.
Where as lambs and sheep which have previous exposure to this parasite (i.e., immunologically sensitized sheep), the larvae produces localized reaction during migration into the mucosa.
During localized reaction leucocytes especially eosinophils, foreign body giant cells collect around the each larva and encapsulated by fibroblast.The larvae stay in the nodules for about three months.
When the contents of the nodule caseate and calcify the larvae either dies or leaves the nodules.
After leaving the nodule, larvae wander in the muscle fibre. But majority of the larvae don’t return to the lumen of the intestine. In such case, large number of nodules and very few adult worms are seen.
Nodules are suppurative in nature and may rupture the peritoneum causing peritonitis.

Pimply Gut

Last modified: Tuesday, 19 June 2012, 8:30 AM

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VPA 211: General Veterinary Parasitology and Helminthology (3+1)

Pathogenesis

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