General-Systemic Pharmacology: Mechanism of action of cardiac glycosides

Mechanism of action of cardiac glycosides

MECHANISM ACTION OF CARDIAC GLYCOSIDES

Mechanisms of inotropic action of cardiac glycosides

Cardiac glycosides produce their action by inhibition of Na⁺, K⁺ transport system (Na⁺, K⁺ -ATPase)
Inhibition of this sodium pump results in increased intracellular Na⁺ concentration
Normally sodium is brought into the cell in exchange for Calcium during the plateau phase
Because of the elevated intracellular Na⁺, sodium - calcium exchanger is not functional, leading to elevated intracellular Ca⁺⁺ levels
Ca⁺⁺ forms a complex with troponin and tropomyosin allowing actin and myosin filaments to come together
Muscle contracts
Altered Na⁺, K⁺ and Ca⁺⁺ levels are the basis for both the therapeutic and toxic effects of the cardiac glycosides.

Last modified: Wednesday, 25 April 2012, 10:48 AM

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VPT 311: General and Systemic Veterinary Pharmacology (2+1)

Mechanism of action of cardiac glycosides

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