General-Systemic Pharmacology: Pharmacological effects of cardiac glycosides

Pharmacological effects of cardiac glycosides

PHARMACOLOGICAL EFFECTS OF CARDIAC GLYCOSIDES

Positive inotropic effect is noticed by improved emptying and reduction in size of the dilated failing heart.
The muscle contracts more quickly and more powerfully for the same filling stimulus and for the same oxygen consumption.
So venous pressure is reduced, oedema fluid is reabsorbed and blood pressure increases.
Negative chronotropic effects by direct stimulation of the vagal centre and by slowing the rate of passage of impulses through the conducting system.
Diuretic effect due to increased blood flow and increased glomerular filtration rate.

Last modified: Wednesday, 25 April 2012, 10:49 AM

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VPT 311: General and Systemic Veterinary Pharmacology (2+1)

Pharmacological effects of cardiac glycosides

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