VPT 311: General and Systemic Veterinary Pharmacology (2+1)

PHARMACOTHERAPEUTICS OF WATER SOLUBLE VITAMINS

Vitamin	Deficiency sign	Treatment
B1 Thiamine	Bracken fern poisoning Nervous signs	Calf - 5 - 50 mg Sheep 20- 200 mg Cat 1- 20 mg Dog 5-50 mg Horse / Ox 100 - 1000 mg PO or IM or SC
B2 Riboflavin	Curled toe paralysis in chicken, anaemia, dermatitis, csours in calves, low fertility, eye discharge, photophobia in horse	Pig 5 mg / day Horse 40 mg / day in feed
B3 pyridoxine	Acrodynia (dermatitis, hyperkeratinization) in dogs, degeneration of spinal and peripheral nerves	Same as thiamine
Nicotinic acid	Pellagra, Black tongue in dog, rough skin, Oral ulcers, diarrhoea, dermatitis	Dog - 5-10 mg / kgIM Cat 10 - 30 mg / kg IM Calf 25 mg / day SC Pig 0.1 - 0.3 gm SC or 0.2 - 0.9 gm orally
B12 Hydroxycobalamin	Bush sickness, hind limb weakness, incoordination, hair or wool loss, stunted growth, anaemia	Dog and Cat - 2-4 µg/ kg / day IM
Biotin	Fatty liver if fed entirely on wheat ration Egg white contains antibiotin factor Avidin	100 µg / chick / day PO
Choline	Perosis (slipped tendon) in poultry Ataxia in dogs, cats and pigs	Dog 550 mg / day PO CAt 25 - 50 mg / kg day PO or SC Also in milk fever or ketosis in cattle and buffaloes
Ascorbic acid (Vitamin C)	No definite signs	Horse 2-4 gm SC Bull 1-2 gm Sc Cow 1-2 gm IV or SC before mating Dog 25 - 75 mg / day PO or SC