Pathogenesis

PATHOGENESIS
  • Most infections are endogenous in origin and predisposing causes such as immunosuppression, prolonged antibiotic therapy and malnutrition.
  • Disseminated candidiasis (or) systemic candidiasis is more common in immunosuppressed animals.
  • Candida possesses adhesions consisting of fibrillar peptide, Mannans, which have an affinity for the fibronectin on the surface of cells.
  • The yeast forms are responsible for tissue damage.
  • Inhibition of yeast cell division results in hyphal elements that invade tissues.
  • Possible virulence factors are cell wall glycoprotein, proteases, neuraminidase, chitin, mannoprotein and lipids.
  • The cell-wall glycoproteins have an endotoxin like activity.
  • Infection caused by C.albicans frequently involves mucous membranes. Granulomatous lesions are rare.
Last modified: Monday, 4 June 2012, 5:58 AM