VPT 321: Veterinary Neuropharmacology (2+1) copy 1

PRINCIPLE

Magnetic Eddy’s Hot plate

• This is a direct thermal stimulus method. - In this method the hot plate is heated upto a temperature of 55 + 5 degree celcius.
• The hot plate is covered with a persplex cover with a lid so as to avoid animal jumping from the hot plate once it evinces pain.
• Once the instrument is set to the required temperature and switched on.

Principle

• The basic principle involved in methods is to elicit reaction of animals to a standardized painful stimuli before and after administration of the test drug.
• A significant increase in the reaction time after administration of drug indicates its analgesic effect in animals.