VPT 421: Veterinary Toxicology (2+0)

ABSORPTION AND FATE

• At high concentrations naturally occurring seleno-amino acids and soluble selenium salts are readily absorbed.
• Small intestine is the primary absorption site; no absorption takes place in the stomach and rumen.
• Plasma proteins transport absorbed selenium.
• Selenium is metabolized both by reduction and methylation.
• Urine is the major route of excretion in monogastric animals.
• Ruminants excrete significant amounts of selenium in the faeces as well.