Mechanisms of Toxicity

MECHANISM OF TOXICITY

  • Glutathione depletion and lipid peroxidation are probable important factors in toxicosis.
  • Selenium replaces sulphur in amino acids (cysteine and methionine), possibly affecting some essential proteins.
  • Chronic selenosis depresses adenosine triphosphate formation possibly by inhibition of sulphydryl enzymes.
  • Tissue ascorbic acid levels fall, possibly contributing to the vascular damage caused by selenosis.
Last modified: Thursday, 21 April 2011, 3:51 PM