Mechanism of Action

MECHANISM OF ACTION

  • Toxicity of urea and non-protein nitrogen is due to ammonia absorbed from the stomach.
  • When the level of ammonia is high, the animal cannot detoxify ammonia fast because the urea and glutamine synthesizing mechanisms are saturated.
  • Increased ammonia leads to inhibition of citric acid cycle.
  • There is an increase in anaerobic glycolysis, blood glucose and blood lactate.
  • Acidosis is manifested.
  • A decreased energy production and cellular respiration leads to convulsions.
Last modified: Sunday, 4 December 2011, 1:20 PM