Rubratoxins
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Sources
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Rubratoxins A and B are produced by P. rubrum and P. purpurogenum.
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Both are common soil fungi.
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Exposure to the toxin is through cereal grains-primarily corn.
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The natural distribution of rubratoxin is not well established.
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Male and female rats are equally susceptible; but neonates are 49 times as susceptible as adults.
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At sufficient doses, chronic dosing causes same effects; but animals getting subclinical doses had no lesions suggesting effective detoxification.
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Mutagen, embryocidal, teratogenic in mice. So far carcinogenicity has bot been established in rats.
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May potentiate the action of aflatoxin.
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Signs
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Clinical syndrome is similar to acute aflatoxicosis with anorexia, dehydration, diarrhoea and possibly hemorrhage.
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It has been implicated in abortions in swine.
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Lesions
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Acute and chronic syndrome characterized by hepatotoxic insult, nephrosis and general bleeding tendency.
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Congestion, hemorrhage and damage to liver, kidney and spleen.
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Early midzonal hepatic necrosis.
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Later extending to massive necrosis and replacement with hemorrhage with chronic doses.
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Last modified: Sunday, 30 October 2011, 11:02 AM