Toxicokinetics

TOXICOKINETICS

  • Aflatoxins are rapidly absorbed from the gastrointestinal tract.
  • They are bound to serum albumin.
  • Liver removes most of the toxins from the blood stream.
  • In hepatocytes it binds to macromolecules like DNA, endoplasmic sterol binding sites and enzymes.
  • Metabolites formed may be water-soluble conjugates or lipid soluble forms. Some metabolites undergo enterohepatic recirculation.
  • They are excreted in milk, faeces and urine.
  • Complete elimination takes several days.
Last modified: Sunday, 30 October 2011, 10:58 AM