VPT 421: Veterinary Toxicology (2+0)

Differences between organophosphosphates and carbamates

DIFFERENCES BETWEEN ORGANOPHOSPHATES AND CARBAMATES

Organophosphates	Carbamates
Phosphorylates acetylcholinesterase	Carbamylates acetylcholinesterase
Irreversible inhibition of AChE	Reversible inhibition of AChE
Completely inhibits AChE	Incompletely inhibits AChE
Dephosphorylation does not occur easily	Decarbamylation occurs easily
Detach slowly from AChE	Detach easily and rapidly from AChE
Bind only to the esteratic site	Bind to the anionic and esteratic sites
Oximes are useful	Oximes are not useful