VPT 421: Veterinary Toxicology (2+0)

CLINICAL SYMPTOMS AND TREATMENT

Symptoms

• The clinical symptoms are similar to organophosphorus compounds.
• But the symptoms are not long lasting.

Treatment

• Atropine adminstration and symptomatic treatment are useful.
• Oximes (enzyme reactivators) are not useful and they are contraindicated.
• Carbamates attach to both the anionic and esteratic site of acetylcholinesterase and this does not allow oximes site to attach. Oximes themselves are weak anticholinesterase agents and may add on to aggravation of symptoms.
• Hyderochlorothiazide diuretics are also said to be useful.