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6.3.1.3. Oxidation of Pyruvate to Acetyl CoA
Under aerobic condition pruvate derived from glucose by glycolysis, is dehydrogenated to yield acetyl-CoA and CO2 by pyruvate dehydrogenase, located in the mitochondria. The reaction is as follows: Pyruvate Acetyl CoA CH3COCOOH+ NAD+ + CoA-SH → CH 3 S ~ CoA+ NADH + CO2 Thiamine pyrophosphate, coenzyme A, lipoic acid and NAD+ are coenzymes needed for the reaction. The acetyl CoA is then fed into citric acid cycle and oxidized to CO2 in citric acid cycle and energy is producd. |
Last modified: Tuesday, 28 February 2012, 10:29 AM