Abnormalities of the cellular elements of the blood

ABNORMALITIES OF THE CELLULAR ELEMENTS OF THE BLOOD

Anemia in Farm Animals

  • Etiology
    • Hemorrhagic anemia
      • As for hemorrhagic blood loss.
  • Cattle
    • Babesiosis, anaplasmosis, eperythrozoonosis, trypanosomiasis, theileriosis
    • Bacillary hemoglobinuria
    • Leptospirosis in claves (Leptospira interogans serovar Pomona)
    • Postparturient hemoglobinuria
    • Plant poisons in Brassica spp., Mercurialis, Pimelea, Alliums.
    • Feeding cannery offal of onions, tomatoes
    • Poisoning by phenothaizine, guaifenesin, chronic cooper, especially in calves
    • Rarely in treatment with long acting tetracycline
    • In a transfusion reaction
    • Congential isoerythrolysis due to vaccination of dam with blood-derived vaccination, e.g., anaplasmosis
    • Autoimmune hemolytic anemia in young calves
    • Inherited dyserythropoieses in Polled Herefords
    • Congential anemia in Murray Grey cattle due to cell membrane delect
  • Sheep
    • Chronic copper poisoning , primary due to excessive intake, secondary due to ingestion pyrrolizidine alkaloids.
    • Eperythrozoonosis, babesiosis
    • Plant toxins in Brascia, Alliums pp.
    • Fasciola, Haemonchus spp infestations
    • Lambs fed cow colostrum from rare individual cows
  • Horses
    • Equine infectious anemia
    • Babesiosis
    • Phenothiazine poisoning
    • Alloimmune hemolytic anemia
    • Antoimmune hemolytic anemia
    • Penicillin-induced hemolytic anemia

Nutritional deficiency anemia

  • Copper-ruminants
  • Cobalt-ruminants
  • Iron- piglets and claves
  • Potassium, possibly in claves
  • Pyridoxine, experimentally
  • Folic acid. Some response to supplementation in horses

Anemia secondary to chlorine disease

  • Chronic supporative processes
  • Radiation injury
  • Poisoning by:
    • Ptaquilsode
    • Trichlorethylene extracted soybean meal
    • Arsenic
    • Furazolidone
  • Phenylbutazone
  • Sequel to inclusion body rhinitis of pigs
  • Osteragiasis , trichostrongylosis in claves and lambs
  • Temporarily after moving to high altitude

Myelopthisic anemia

  • Lymphosarcoma in calves
  • Plasma cell myelomatosis in claves , pigs and horses
  • Melofibrosis in horses

Miscellaneous anemias

  • Equine unspecified anemia

Clinical findings

  • All signs
    • Except reduced physical performance, as in racing-limited to occurrence when anemia already severe
    • Mucosal pallor
    • Depression
    • Anorexia
    • Weakness, shuffling gait, tremor, terminal recumbency
    • Tachybency
    • Large amplitude (bounding ) pulse
    • Marked increase in heart beat intensity; loud sounds, exaggerated beat
    • Heart dilation
    • Hemic systolic murmur, maximum at inspiration peak
    • Deep sighing respiration short of dyspnea until late stages
    • Associated signs include edema, hemoglobinuria, jaundice

Clinical pathology

  • Hemoglobin level reduced; clinical signs at 50% reduction, below 20% incompatible with life
  • Erythocyte count, packed cell volume reduced
  • Immature erythrocyte numbers increased in hemorrhagic, hemolytic anemia except in horses
  • No evidence of erythrocyte regeneration in chronic disease anemia
  • Hypoproteinemia in hemorrhagic anemia
  • Serum and plasma discolored due to hemoglobin, and hemoglobinuria in hemolytic anemia
  • Hypochromasia in nutritional deficiency of iron
  • Bone marrow biopsy essential for diagnosis of myelophthistic anemia

Diagnosis

  • Resembles
    • Hemorrhagic blood loss
    • Hemorrhagic disease
    • Shock
    • Shortfall
    • Performance
    • Ill-thrift
    • Poor performance
    • Blood transfusion in critical cases
    • Treatment of specific cause, possibly verified by response trial
    • Hematinic preparation, especially iron administered orally, supportively; organic iron parenterally for more prolonged effect
    • Corticosteroids in autoimmune anemia
Last modified: Tuesday, 5 June 2012, 12:58 PM