Organo Phosphates

ORGANO PHOSPHATES
  • Organo phosphates are neutral esters of phosphoric acid or its analogue. They act by inhibiting the action of acetylcholine esterase (AchE) at cholinergic synapses and at muscle end plates
  • Organophosphosphates mimics the structure of Ach and when it binds AchE causes transphosphorylation of enzyme, this transphosphorylated AchE is unable to break down  and  accumulates as Ach at post synaptic membrane leading to neuromuscular paralysis
  •  Degree of transphosphorylation of enzyme helps to determine activity of Organo phosphates – it is not reversible - AchE is metabolized by oxidative and hydrolytic enzymes eventually
Last modified: Monday, 9 May 2011, 9:53 AM