Mechanism of action

MECHANISM OF ACTION
  • All antipsychotic drugs have potent dopamine (D2) blocking action.
  • Block the limbic system and mesocortical areas.
  • Mainly block the adaptive changes to blockade of D2 receptors.
  • Firing of dopamine neurons and dopamine turnover increases initially.
  • Over a period of time this subsides and gives way to diminished activity in the basal ganglia.
Last modified: Sunday, 2 October 2011, 4:37 PM