VPT 321: Veterinary Neuropharmacology (2+1) copy 1

FEATURES 

Features of different antipsychotic drugs

• Triflupromazine: More potent than chlorpromazine produce muscle dystonia when injected .
• Thioridazine: Potency is low, marked central anticholinergic action, lowest incidence of extrapyramidal side effects, cardiac arrhythmia and interfere with male sexual function.
• Trifluoperazine, fluphenazine, thioproperazine: Highly potent. Have minimum autonomic action. Cause hypersensitivity reactions. Extrapyramidal side effects are marked. 
• Haloperidol: Potent antipsychotic with few autonomic effects. Less epileptogenic..
• Trifluperidol: Slightly potent than haloperidol
• Droperidol: A short acting neuroleptic, used in combinationn with anaesthesia.
• Penfluridol: A long acting neuroleptic
• Flupenthixol: A less sedative than chlorpromazine.
• Pimozide: A specific Dopamine antagonist. Has a long duration of action, considered for maintenance therapy.
• Loxapine: Action is quick and lasts for 12 hours. Sedation is less but cardiac and neurological toxicity is prominent.
• Clozapine: Is a atypical antipsychotic.. Weak D₂ blocking action. High incidence of agranulocytosis and other blood dyscriasis.
• Risperidone: Block D₂ and 5HT₂ receptors.